Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia H.Laivuori1,2,3,4,6, M.J.Gallaher1, L.Collura1, W.R.Crombleholme1,2, N.Markovic1,5, A.Rajakumar1,2, C.A.Hubel1,2, J.M.Roberts1,2,5 and R.W.Powers1,2
نویسندگان
چکیده
Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA, Department of Clinical Genetics, Helsinki University Central Hospital, Haartman Institute, Department of Medical Genetics, University of Helsinki, Helsinki, Finland and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
منابع مشابه
Comparison of Abdominal Aorta Intima-Media Thickness, Serum Level of Leptin, and Lipid Profile between Maternal Preeclampsia and Neonatal Outcomes
Background Pre-eclampsia is one of the main causes of morbidity and mortality among pregnant women. This study was done with the objective of measuring abdominal aorta intima-media thickness, serum level of leptin, and lipid profile in neonates of pre-eclampsia mothers and comparing them with neonates of mothers without pre-eclampsia (control group). Materials and Methods Ninety neonates of pre...
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Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin i...
متن کاملIncreased leptin concentration in preterm infants of pre-eclamptic mothers.
AIM To study the effect of maternal pre-eclampsia on cord plasma leptin concentrations in preterm infants. METHODS Leptin concentration was analysed in cord plasma of 74 preterm infants, gestational age 24 to 32 weeks. Of these, 14 were born to pre-eclamptic mothers, in 10 intrauterine growth retardation (IUGR) was present, and 59 had been exposed antenatally to corticosteroids. RESULTS The...
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Background: Leptin is a new adipose-derived hormone discovered in 1994. It is vital in energy balance and weight regulation in humans. During pregnancy the placenta is an extra source of leptin. The role of leptin in pregnancy is not established. This has generated a lot of interest in leptin research in pregnancy. Leptin is being examined in pathological states that may have origin in adipose ...
متن کاملLongitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia.
Leptin concentrations have been found to be elevated in cross-sectional studies of established pre-eclampsia. Circulating concentrations of leptin were measured in a cross-sectional study to confirm these findings (19 women with pre-eclampsia and 13 normal pregnant controls) and in a longitudinal study to establish the timing of the increase in leptin concentrations (samples obtained at 16, 20,...
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